The Importance of Luminal Contents in Intestinal Adaptation and Experimental Colorectal Carcinogenesis

4 Chapter Is INTRODUCTION 5 Chapter 2: INCIDENCE AND DISTRIBUTION OF 10 HUMAN COLORECTAL CARCINOMA Chapter 3: EXPERIMENTAL COLORECTAL CARCNOGENESIS 19 Chapter 4: THE AETIOLOGY OE COLORECTAL CANCER 33 A Heredity 34 B Adenoma 39 C Diet 43 D Inflammation 36 E Injury 60 Chapter 3: INTESTINAL CELL PROLIFERATION 65 Chapter 6: SMALL BOWEL ADAPTATION 72 Chapter 7: ADAPTATION AND CARCINOGENESIS 86 IN THE LARGE BOWEL Chapter 8: BILE ACIDS AND BACTERIA IN 94 COLORECTAL CARCINOGENESIS Chapter 9: MATERIALS AND METHODS 100 Chapter 10: EXPERIMENTAL RESULTS 118 A Intestinal adaptation and carcinogenesis 119 after distal ileal resection and bypass B Intestinal adaptation and carcinogenesis 133 in defunctioned colon C Mucosal cell proliferation in defunctioned 149 colon and bowel remaining in continuity D Colorectal carcinogenesis after intrarectal 165 instillation of a bile acid with and without concurrent metronidazole E Effect of bile acids on colonic mucosal 175 cell proliferation and faecal bacterial population E Caecal carcinogenesis following distal transposition 188 Chapter 11: GENERAL DISCUSSION 198